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目的 :观察血清白介素 -8(IL -8)、超氧化物歧化酶 (SOD)和丙二醛 (MDA)在慢性阻塞性肺疾病 (COPD)急性加重期和缓解期的变化并评价其临床意义。方法 :COPD急性加重期病人 2 3例列为观察组 ,选择非呼吸道疾病的同期住院患者 3 0例为对照组。两组年龄、性别无显著差异。分别观察两组病人的IL -8、SOD和MDA ,并进行分析对比。结果 :观察组在急性发作期或缓解期IL -8、MDA与对照组相比均有显著增高 ,SOD降低 ,经治疗IL -8和MDA有显著下降 ,SOD增高。与治疗前比较有显著性差异 (P <0 .0 1,P <0 0 5 )。结论 :测定血清IL -8时 ,结合SOD、MDA测定可有助于反映COPD病情或用于疗效评定。
Objective: To observe the changes of serum interleukin-8 (IL-8), superoxide dismutase (SOD) and malondialdehyde (MDA) in patients with acute exacerbation and remission of chronic obstructive pulmonary disease . Methods: Twenty-three patients with acute exacerbation of COPD were enrolled in the observation group and 30 patients in the same period of non-respiratory disease were selected as the control group. Two groups of age, gender no significant difference. The levels of IL-8, SOD and MDA in the two groups were observed and compared. Results: The levels of IL-8 and MDA in the observation group were significantly higher than those in the control group during acute exacerbation or remission stage, while the levels of SOD and SOD were decreased. The levels of IL-8 and MDA in the observation group decreased significantly and SOD increased. There was a significant difference between before and after treatment (P <0.01, P <0.05). Conclusion: The determination of serum IL -8, combined with SOD, MDA determination may help to reflect the condition of COPD or for the evaluation of the curative effect.