消化性溃病(Pu)是一种古老的疾病、是多发病。Pu并非是单一疾病而是以消化道溃疡为基础表现出来的全身性疾病,它的病因复杂,归纳起来Pu的发生是由于攻击因子和防御因子失去平衡而引起,攻击因子包括胃酸、胃蛋白酶、胃肠激素、胃肠动力失调、幽门螺旋菌(HP)、某些药物如皮质激素及非甾体类药(NSAID)等。防御因子有粘膜屏障、粘膜血流微循环、前列腺素、上皮再生等。但诸多因素中对Pu的发生“酸”仍然如1910年Cchwatz的名言 Peptic ulcer disease (Pu) is an ancient disease, is frequently-occurring disease. Pu is not a single disease but a systemic disease based on peptic ulcer. The etiology of Pu is complicated by the fact that Pu is caused by the imbalance of attack and defense factors such as gastric acid, pepsin, Gastrointestinal hormones, gastrointestinal motility disorders, Helicobacter pylori (HP), certain drugs such as corticosteroids and non-steroidal drugs (NSAID) and so on. Defense factor mucosal barrier, mucosal blood flow microcirculation, prostaglandins, epithelial regeneration. However, the occurrence of Pu in many factors remains the same as that of Cchwatz in 1910