许多心血管疾病如原发性高血压的发生和发展,均与血管内皮细胞结构的损伤和功能异常有密切关系。而血管内皮细胞的损伤,一方面可以导致一氧化氮(nitric oxide,NO)合成减少及分泌异常,另一方面也使细胞膜对钙离子处理异常。NO和Ca2+可通过各自和两者之间的相互作用对原发性高血压的发生和发展起到重要的调控作用。 Many cardiovascular diseases such as the occurrence and development of essential hypertension are closely related to the damage and dysfunction of the vascular endothelial cell structure. The damage of vascular endothelial cells, on the one hand can lead to nitric oxide (NO) synthesis and secretion abnormalities, on the other hand also make the cell membrane calcium ion processing abnormalities. NO and Ca2 + can play an important regulatory role on the occurrence and development of essential hypertension through their own and their interaction.