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大承气汤是治疗肠梗阻的著名方剂。本文按中医治疗急性肠梗阻以“通里攻下”法为主,“清热解毒”、“活血化淤”法为辅的原则,设计了三种肠梗阻的病态动物模型,用九项药理指标对大承气汤进行在体、离体、体内、体外等多方面的药理作用研究。结果证明“通里攻下”作用出现最快,以正交设计的四项药理指标均能反映“以通为用”的原则,药效以全方最强。相继出现的药效反应也说明“清热解毒”、“活血化淤”两法在治疗急性肠梗阻中确有抑制菌性炎症的扩散、减少渗出、减轻或消除粘连以及增加肠系膜微循环血流速度,改善缺血肠段的血行不畅等作用。
Dachengqi Decoction is a famous prescription for treating intestinal obstruction. According to the principle of Chinese medicine treatment of acute intestinal obstruction based on the “Tongli attack” method and the principle of “clearing heat and detoxification” and “blood stasis and detoxification”, the diseased animal models of three kinds of intestinal obstruction were designed and nine pharmacological indexes were used. Dachengqi Decoction has been studied in vivo, ex vivo, in vivo, and in vitro. The results showed that the “Tongli attack” had the fastest effect. The four pharmacological indexes designed by orthogonal design can all reflect the principle of “use for communication”, and the pharmacological effect is the strongest in all aspects. The pharmacodynamic responses that appeared one after another also indicated that the methods of “clearing heat and detoxicating” and “blood stasis and detoxification” did indeed inhibit the spread of bacterial inflammation, reduce exudation, reduce or eliminate adhesions, and increase the microcirculation of mesenteric microcirculation in the treatment of acute intestinal obstruction. Speed, improve blood circulation in ischemic bowel and other effects.