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目的探讨影响脑卒中高危人群颈动脉硬化及斑块形成的相关危险因素。方法对3215例脑卒中高危人群进行颈动脉B超筛查,根据内膜是否增厚及斑块数量进行分组,比较各组内膜是否增厚、斑块数量与高危因素间的相互关系。结果脑卒中高危人群中有内膜增厚组与无内膜增厚组在性别、血脂异常、糖尿病病史方面差异有统计学意义(P<0.05);斑块数量不同组人群在性别、吸烟与否、超重、卒中家族史差异有统计学意义(P<0.05);多因素Logistic回归分析显示,颈动脉内膜增厚与否与血脂异常、糖尿病明显相关;内膜增厚与否在虚证患者中差异有统计学意义(P<0.05)。结论血脂异常、糖尿病可能是颈动脉内膜增厚的独立危险因素;斑块形成的多少受吸烟、超重、卒中家族史影响更明显。在有颈动脉内膜增厚患者中虚证较实证更多见。
Objective To explore the related risk factors affecting carotid atherosclerosis and plaque formation in high-risk stroke population. Methods A total of 3215 high-risk stroke patients were screened by B-mode carotid artery. According to whether the intima was thickened and the number of plaques, we compared the relationship between the thickening of intima and the number of plaque and risk factors in each group. Results There were significant differences in the history of sex, dyslipidemia and diabetes mellitus between the intimal thickening group and the intima thickening group at high risk of stroke group (P <0.05). There were significant differences in the gender, smoking and (P <0.05). Multivariate Logistic regression analysis showed that carotid intima-media thickness was related to dyslipidemia and diabetes mellitus, and whether intima thickening or not was on the basis of deficiency syndrome The difference was statistically significant (P <0.05). Conclusions Dyslipidemia and diabetes mellitus may be independent risk factors of carotid artery intima thickening. The number of plaque formation is more affected by smoking, overweight and family history of stroke. In patients with carotid artery intimal thickening evidence is more common evidence.