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目的研究急性脑梗死后血清血小板衍生内皮细胞生长因子浓度(PD-ECGF)变化与神经功能缺损的关系。方法测定60例脑梗死患者发病后24h内、第3天、第7天、第14天的PD-ECGF浓度,同步评估美国国立卫生研究院脑卒中量表(NIHSS)评分,并记录脑梗死的体积。结果脑梗死患者发病后24h内、第3天、第7天、第14天的平均血清PD-ECGF浓度分别为(4 080.62±1 569.27)、(4 386.03±1 746.05)、(5 473.24±2 312.75)、(3 365.72±1 421.76)pg/ml,4个时点间的差异有统计学意义(F=14.297,P<0.05),并均高于对照组(2 687.92±950.60)pg/ml。相应时点的NIHSS评分分别为(6.35±4.09)、(6.25±4.45)、(5.42±4.44)、(4.68±4.49)分,4个时点间的差异无统计学意义(F=1.925,P>0.05)。发病后第3天脑梗死体积与血清PD-ECGF浓度无相关性(r=0.107,P>0.05),但与NIHSS评分具有相关性(r=0.619,P<0.05)。结论血清PD-ECGF浓度在脑梗死后即有升高,但浓度的高低与神经功能缺损程度和康复无关,与急性脑梗死的病理生理过程相一致。
Objective To study the relationship between the changes of serum platelet-derived endothelial cell growth factor (PD-ECGF) and neurological deficits after acute cerebral infarction. Methods The concentrations of PD-ECGF in 60 patients with cerebral infarction at 24 h, 3 d, 7 d and 14 d after onset were measured and the NIH Stroke Scale (NIHSS) score was simultaneously evaluated. The cerebral infarction volume. Results The average serum PD-ECGF concentrations on the 3rd, 7th and 14th days after onset of cerebral infarction were (4 080.62 ± 1 569.27), (4 386.03 ± 1 746.05), (5 473.24 ± 2) 312.75) and (3 365.72 ± 1 421.76) pg / ml, respectively. The difference between the four time points was statistically significant (F = 14.297, P <0.05) and higher than that of the control group (2 687.92 ± 950.60) pg / . NIHSS scores at the corresponding time points were (6.35 ± 4.09), (6.25 ± 4.45), (5.42 ± 4.44) and (4.68 ± 4.49) points respectively, with no significant difference between the four time points (F = 1.925, P > 0.05). There was no correlation between cerebral infarction volume and serum PD-ECGF concentration on the third day after onset (r = 0.107, P> 0.05), but there was a correlation with NIHSS score (r = 0.619, P <0.05). Conclusions The concentration of PD-ECGF in serum increases after cerebral infarction, but the concentration of PD-ECGF is not related to the degree of neurological deficit and rehabilitation, which is consistent with the pathophysiological process of acute cerebral infarction.