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用３号渔线经颈内动脉阻塞右侧大脑中动脉（ＭＣＡＯ）的方法，造成局灶性脑缺血模型，观察了右侧ＭＣＡＯ后、２小时和４小时大脑皮层各微区脑血流量的动态变化；同时探讨了不同剂量的“微循环Ⅰ号”对局灶性脑缺血后脑皮层微区脑血流量的影响。结果发现：与阻塞前和假手术组比较，右侧顶叶、额叶微区脑血流量在阻塞后、２小时和、４小时均有显著性差异（Ｐ＜０．０５），而左顶叶和额叶无统计学意义（Ｐ＞０．０５），右顶微区脑血流量阻塞后２小时、４小时用药组与ＭＣＡＯ未用药组比较有显著差异（Ｐ＜０．０５）。结果表明右侧大脑中动脉阻塞后右顶叶、额叶微区脑血流量明显降低，说明微循环Ⅰ号能提高右侧脑皮层的血流量。
The model of focal cerebral ischemia was established by blocking the right middle cerebral artery (MCAO) with No.3 line through the internal carotid artery. The cerebral micro-area cerebral blood flow in the cerebral cortex at 2h and 4h after MCAO was observed The effects of different doses of microcirculation Ⅰ on the cerebral blood flow in the cerebral cortex after focal cerebral ischemia were also discussed. The results showed that compared with pre-occlusion group and sham-operated group, there was a significant difference (P <0.05) in cerebral blood flow in the right parietal lobe and frontal lobe after obstruction, 2 hours and 4 hours There was no significant difference in leaf and frontal lobe between the two groups (P> 0.05). There was a significant difference between the two groups at 2h and 4h after MCAO (P <0.05). The results show that the right middle cerebral artery occlusion right parietal lobe, frontal lobe micro area cerebral blood flow decreased significantly, indicating microcirculation Ⅰ can improve the right cerebral cortex blood flow.