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To investigate the effect of orthotopic liver transplantation on fulm inant hepatitis B and the preventive efficiency of lamivudine on recurrence of h epatitis B in China. Patients and methods. Ten patients with fulminant hepatitis B received orthotopi c liver transplantation under veno venous bypass. All patients had preoperative ly serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy , 2 with acute renal failure, and 1 with gastro hemorrhage. Rusult. Seven of the 10 patients have survived for 3～18 months, but 3 died of m ulti organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3～18 months without the signs of re currence of hepatitis B. Conclusion. Orthotopic liver transplantation is an effective therapy for fulmina nt hepatitis B, and lamivudine may prevent recurrence of hepatitis B after trans plantation.
To investigate the effect of orthotopic liver transplantation on fulm inant hepatitis B and the preventive efficiency of lamivudine on recurrence of h epatitis B in China. Patients and methods. Ten patients with fulminant hepatitis B received orthotopi c liver transplantation under veno venous bypass. All patients had preoperative ly serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro hemorrhage. Rusult. Seven of the 10 patients have survived for 3 to 18 months, but 3 died of m ulti organ failure or recurrence of fulminant hepatitis B Seven survivors took lamivudine and 6 of them have survived for 3 ~ 18 months without the signs of re currence of hepatitis B. Conclusion. Orthotopic liver transplantation is an effective therapy for fulmina nt hepatitis B, and lamivudine may prevent recurrence of hepatitis B after trans plantation.