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本文旨在评价儿童和成人口眼氨茶碱的药理动力学。59例支气管哮喘的儿童,年龄1～18岁,平均9.9岁,114例慢性阻塞性肺疾病的成人,年龄20～85岁,平均54岁。在首次口服氨茶碱后至少36小时和第2次有效剂量的1小时内抽血测定茶碱浓度,然后再推算其表面茶碱廓清率(A.T.C)。为使研究结果正确,令患者在抽血前至少36小时不进含黄嘌呤等影响测定的药物、食物或饮料。59例儿童的平均表面茶碱廓清率为84.8毫升/小时/公斤,114例成人为51.4毫升/小时/公斤。再将59例儿童分成两组,年龄较小(1～9岁)组为93.8毫升/小时/公斤,年龄较大(10～18岁)组为77.3毫升/小时/公斤。在进行连续的口服氨茶碱疗法时,根据
This article aims to evaluate the pharmacokinetics of ocular aminophylline in children and adults. 59 children with bronchial asthma, aged 1 to 18 years, mean 9.9 years, 114 adults with chronic obstructive pulmonary disease, aged 20 to 85 years, mean 54 years. Theophylline concentration was determined by taking a blood sample at least 36 hours after the first oral administration of aminophylline and one hour after the second effective dose, and then calculating the apparent theophylline clearance rate (A.T.C.). In order to make the research result correct, the patient should not enter into the drug, food or drink which is affected by xanthine at least 36 hours before blood drawing. The average surface theophylline clearance rate was 84.8 ml / hr / kg in 59 children and 51.4 ml / hr / kg in 114 adults. Fifty-nine children were divided into two groups: 93.8 ml / hr / kg for the younger (1-9 years) and 77.3 ml / hr / kg for the older (10-18 years) group. In the continuous oral aminophylline therapy, according to