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目的调查深圳地区超重及肥胖青少年血糖、血脂水平及进行2型糖尿病和高危者筛查。方法2 138例7～15岁学生作为调查对象进行身高、体质量测量,筛选出201例自愿接受调查的肥胖者进行采集空腹肘静脉血测定血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和空腹血糖(FPG)及口服葡萄糖耐量试验,测定各项指标。结果正常、超重、肥胖三组间TG,HDL-C,LDL-C差异均有统计学意义(P<0.01)。FPG,TG,HDL-C,LDL-C的异常检出率在不同体型组间差异均有统计学意义(P<0.05)。肥胖组的2 h血糖显著高于超重组和正常组,且糖代谢异常的发生率显著高于另两组(P<0.001)。本调查共发现2型糖尿病1例,糖耐量异常(IGT)11例。结论超重和肥胖青少年较体质量正常者存在明显的血糖和血脂异常。应加强超重和肥胖青少年血糖和血脂检测,并进行综合干预。
Objective To investigate the level of blood glucose and blood lipid in overweight and obese adolescents in Shenzhen and to screen for type 2 diabetes and high risk. Methods Totally 201 adults aged 7-15 years were enrolled in this study. Body mass and body mass were measured. 201 obese volunteers who were surveyed voluntarily were selected to collect fasting cubital vein blood samples for determination of serum total cholesterol (TC), triglyceride (TG) High-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FPG) and oral glucose tolerance test were measured. Results There were significant differences in TG, HDL-C and LDL-C between normal, overweight and obesity groups (P <0.01). The detection rate of abnormalities of FPG, TG, HDL-C and LDL-C in different body types were statistically significant (P <0.05). The 2 h blood glucose in obese group was significantly higher than that in overweight and normal controls, and the incidence of abnormal glucose metabolism was significantly higher than that in the other two groups (P <0.001). The survey found 1 type 2 diabetes, impaired glucose tolerance (IGT) in 11 cases. Conclusion Overweight and obese adolescents have obvious blood glucose and dyslipidemia compared with those with normal body weight. Should be strengthened overweight and obesity in adolescents blood glucose and blood lipid testing, and comprehensive intervention.