角膜病是一类严重的致盲眼病,而角膜新生血管(CNV)是角膜化学伤、外伤、感染等多种疾病的共同病理改变。导致CNV形成的原因仍不明确。血管内皮生长因子(VEGF)可能是CNV形成中最主要的血管形成因子。CNV的治疗方法包括药物、手术和激光等,但效果均不理想。RNA干扰技术给CNV机制研究和治疗带来新的思路。使用siRNA针对恰当的基因靶点产生沉默效应,是治疗CNV的潜在有效途径。 Corneal disease is a type of severe eye disease that causes blindness. Corneal neovascularization (CNV) is a common pathological change in many diseases such as corneal chemical injury, trauma and infection. The cause of CNV formation is still not clear. Vascular endothelial growth factor (VEGF) may be the most important angiogenic factor in CNV formation. CNV treatment includes drugs, surgery and laser, but the effect is not satisfactory. RNA interference technology to CNV mechanism research and treatment brings new ideas. The use of siRNAs to generate silencing effects on appropriate gene targets is a potentially effective way of treating CNV.