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通过特异性强的酶免疫PAP杂色方法,我们对一系列临床宫颈疾患中人乳头瘤病毒(HPV)和疱疹病毒Ⅱ型(HSV—2)抗原进行了检测,并分析了空泡细胞与抗原检出率的关系:结果表明,慢性宫颈炎、宫颈不典型增生和浸润性宫颈癌中HPV和HSV—2抗原的检出率分别为:0,41.2％;31.3％,50.0％;2.1％,62.8％;仅有两例不典型增生和1例浸润性宫颈癌中同时测到两种病毒的抗原。空泡细胞(Koilocyte)的阳性率在慢性炎症为0,不典型增生为72.2％,浸润性癌为16.4％;11例空泡细胞阳性的不典型增生中有4例测到了HPV抗原,但12例空泡细胞阳性的不典型增生中也有6例HSV—2抗原阳性。实验结果提示,宫颈癌的病毒病因:HSV—2和HPV可能均与官颈癌的发生有关,空泡细胞做为诊断HPV感染的特征性标志,值得怀疑。
We examined HPV and HSV-2 antigens in a series of clinical cervical disorders by using a specific and specific enzyme-linked immunostaining method for PAP varicocele, and analyzed the relationship between vacuolar cells and antigens The results showed that the detection rates of HPV and HSV-2 antigen in chronic cervicitis, cervical dysplasia and invasive cervical cancer were 0, 41.2%, 31.3%, 50.0%, 2.1% 62.8%; only two cases of atypical hyperplasia and one case of invasive cervical cancer were detected simultaneously with the two antigens of the virus. The positive rate of Koilocyte was 0 in chronic inflammation, 72.2% in atypical hyperplasia and 16.4% in invasive carcinoma. HPV antigen was detected in 4 of the 11 cases with vacuolar cell-positive dysplasia, but 12 Cases of vacuolar cell-positive dysplasia also had 6 cases of HSV-2 antigen-positive. The experimental results suggest that the cause of cervical cancer virus: HSV-2 and HPV may be associated with the occurrence of cervical cancer, as the identification of vacuolar cells as a characteristic HPV infection markers, is questionable.