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本实验包括①F344大鼠直接黑38(DB38)200ppm食粉饲养4wk②SD大鼠DB381500ppm食粉饲养32wk,③同②组,但以375mg每wkl次灌胃试验。各组均平行作抗菌素肠道细菌干预和单纯抗菌素而不施用DB38的对照组,试验结束后全部内脏作组织病理学检查。4wkF344大鼠DB38饲养组显示肝内卵圆细胞和胶原纤维增生较抗菌素干扰组为严重,统计学差异极显著x2=36.29,P<0.0001),单纯抗菌素组皆正常。SD大鼠灌胃组第24wk发生1例、第32wk发生3例、共4例淋巴细胞样白血病。而饲养组在第24wk、32wk各发生1例。与单纯抗菌素对照组比较,前者有显著差异(P<0.05)后者差异不显著,两个相应的抗菌素干扰组皆在第32wk各发生1例同样病变。显示抑制肠道菌可以延迟和降低DB38导致的白血病。
This experiment included 1F344 rat direct black 38 (DB38) 200ppm feeding powder 4wk2SD rat DB381500ppm feeding powder 32wk, 3 and 2 groups, but 375mg per wkl gavage test. All groups were treated with antibacterial intestinal bacteria and antibiotics without DB38 in parallel. After the end of the experiment, all organs were examined histopathologically. 4wkF344 rat DB38 feeding group showed that the hepatic oval cells and collagen fibrosis were more severe than the antibiotic interference group, and the statistical difference was extremely significant (x2=36.29, P<0.0001). The single antibiotic group was normal. In SD rats, there was 1 case at 24wk, 3 cases at 32wk, and 4 cases of lymphoid leukemia. In the rearing group, 1 case occurred at each of 24th and 32wk. Compared with the control group with simple antibiotics, the former had significant differences (P<0.05). The latter showed no significant difference. The two corresponding antibiotic interference groups all had the same lesion at the 32nd week. It has been shown that inhibition of gut bacteria can delay and reduce DB38-induced leukemia.