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为了初步探讨ＰＤＴ与热损伤对正常胃损伤作用机制的差异，本实验以血卟啉衍生物及氩离子泵染料激光器为光敏剂及光源，观察了大鼠胃壁在单纯氩离子激光照射和ＰＤＴ时，照射部位的温度及组织学在照射后７２小时和二周的改变。结果：氩离子激光照射组和ＰＤＴ组胃壁温度均高于对照组（Ｐ＜０．０１），但ＰＤＴ组温度均低于３７℃。氩离子激光照射后的胃壁组织在７２小时各层组织均明显出血，炎细胞浸润，组织凝固坏死。电镜下见胶原纤维肿胀，排列紊乱，甚至溶解吸收。二周后损伤部位以纤维瘢痕组织修复。ＰＤＴ组在７２小时胃壁组织也有充血和炎细胞浸润，但仅有轻度组织坏死，损伤深度未超过粘膜下层。电镜下见胶原纤维结构基本正常。二周后损伤部位以组织再生修复，未留瘢痕。结论：ＰＤＴ与氩离子激光组织损伤及修复方式不同，ＰＤＴ不损伤胃粘膜下胶原纤维。
In order to investigate the mechanism of PDT and heat injury on normal gastric injury, we used hematoporphyrin derivative and argon ion dye dye laser as photosensitizer and light source to observe the effect of laser irradiation and PDT , The temperature of the irradiation site and the changes of histology at 72 hours and two weeks after irradiation. Results: The temperature of gastric wall in argon laser irradiation group and PDT group were higher than that in control group (P <0.01), but the temperature in PDT group was lower than 37 ℃. Argon ion laser irradiation of the gastric wall tissues in 72 hours were significantly bleeding, inflammatory cell infiltration, tissue coagulation and necrosis. Electron microscope, collagen fibers swollen, arranged disorder, and even dissolved and absorbed. Two weeks after the injury site to repair fibrous scar tissue. The PDT group also had hyperemia and inflammatory cells infiltration in the stomach wall tissue at 72 hours, but only mild tissue necrosis, the depth of injury did not exceed the submucosa. Under the electron microscope, collagen fiber structure was basically normal. Two weeks after the injury site to tissue regeneration and repair, leaving no scar. Conclusion: PDT is different from argon ion laser in the way of tissue damage and repair. PDT does not damage the gastric submucosal collagen fibers.