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目的探讨同型半胱氨酸(homocysteine,Hcy)与胱抑素C(cystatin C,Cys C)在良、恶性胸腔积液鉴别诊断中价值。方法 82例胸腔积液患者均行胸腔镜下胸膜活检,组织病理证实良性胸腔积液患者35例(良性组),恶性胸腔积液患者47例(恶性组),检测2组胸腔积液Hcy和Cys C水平,并进行比较。结果恶性组胸腔积液Hcy水平[(23.54±7.25)μmol/L]高于良性组[(9.75±2.66)μmol/L],Cys C水平[(3.58±0.73)mg/L]高于良性组[(1.86±0.46)mg/L],差异均有统计学意义(P<0.05)。结论恶性胸腔积液患者胸腔积液中Hcy和Cys C水平明显增高,Hcy和Cys C可作为诊断恶性胸腔积液的指标。
Objective To investigate the value of homocysteine (Hcy) and cystatin C (Cys C) in the differential diagnosis of benign and malignant pleural effusions. Methods Thirty-two patients with pleural effusion underwent thoracoscopic pleural biopsy. Histopathological examination confirmed 35 cases of benign pleural effusion (benign group) and 47 cases of malignant pleural effusion (malignant group). Hcy of pleural effusion Cys C levels and compare. Results The level of Hcy in pleural effusion in malignant group was significantly higher than that in benign group [(23.54 ± 7.25) μmol / L, [9.75 ± 2.66] μmol / L] and [3.58 ± 0.73 mg / L] [(1.86 ± 0.46) mg / L], the difference was statistically significant (P <0.05). Conclusions The levels of Hcy and Cys C in pleural effusion were significantly increased in patients with malignant pleural effusion, and Hcy and Cys C could be used as indexes in the diagnosis of malignant pleural effusion.