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目的:探讨复方炎平(YP)抗喘机制。方法:观察 YP 对大鼠肥大细胞体外脱颗粒的影响。观察 YP 对致敏豚鼠离体回肠纵肌白三烯 D_4(LTD_4)受体的阻断作用。结果:YP100μg/ml 即可明显抑制大鼠肥大细胞脱颗粒、明显阻断豚鼠回肠纵肌LTD_4受体,具有剂量依赖性。结论:YP 可通过稳定肥大细胞膜、抑制致敏介质组胺及 LTD_4的释放及阻断 LTD_4受体而发挥抗喘作用。
Objective: To explore the anti-asthma mechanism of compound Yanping (YP). Methods: The effect of YP on the degranulation of rat mast cells in vitro was observed. Observed YP on the sensitized guinea pig isolated ileum longitudinal leukotriene D_4 (LTD_4) receptor blocking effect. RESULTS: YP100μg/ml could significantly inhibit the degranulation of rat mast cells and significantly blocked LTD_4 receptor in guinea pig longitudinal muscle, which was dose-dependent. Conclusion: YP can exert anti-asthma effect by stabilizing mast cell membrane, inhibiting the release of sensitized mediators histamine and LTD_4, and blocking LTD_4 receptor.