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目的观察不同灌注介质对肝脏射频消融灶的影响。方法中华小型猪5头,超声引导下经皮穿刺肝脏进行灌注型射频消融,每只动物接受3次操作,分别灌注50%乙酸溶液、0.9%NaCl溶液以及蒸馏水,共得到15个凝固坏死灶。射频结束后处死动物取肝脏观察,比较消融灶的形态及体积。结果0.9%NaCl溶液组与蒸馏水组的凝固性坏死灶呈边界清楚的圆形或椭圆形,50%乙酸溶液组边界不规则;凝固性坏死灶最小径比较,蒸馏水组与其他2组之间的差异有统计学意义,而0.9%NaCl溶液组与50%乙酸溶液组之间的差异无统计学意义。凝固性坏死灶的体积比较,3组之间的差异有统计学意义。结论使用50%乙酸作为灌注介质对射频消融的增效作用大于生理盐水,蒸馏水作用最小。
Objective To observe the effects of different perfusion media on hepatic radiofrequency ablation. Methods Five Chinese miniature pigs were treated with percutaneous transhepatic radiofrequency ablation under the guidance of ultrasound. Each animal received three times of operation and were perfused with 50% acetic acid solution, 0.9% NaCl solution and distilled water, respectively. A total of 15 coagulation necrosis lesions were obtained. Animals were sacrificed after the radio frequency to take the liver to observe the morphology and volume of the lesion. Results In the 0.9% NaCl solution group and the distilled water group, the coagulation necrosis showed a clear circle or oval shape, the border of the 50% acetic acid solution group was irregular, and the minimum diameter of the coagulation necrosis was compared with that in the distilled water group and the other two groups The difference was statistically significant, but there was no significant difference between 0.9% NaCl solution and 50% acetic acid solution. The volume of coagulation necrosis compared, the difference between the three groups was statistically significant. Conclusion The synergistic effect of 50% acetic acid as a perfusion medium on radiofrequency ablation is greater than that of saline, and distilled water has the least effect.