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Objective: To explore the clinical effect of Duhuo Jisheng Decoction in the treatment of lumbar disc hiation. Methods: CNKI, VIP, Wan Fang Data, Pubmed, Cochrane Library, Medline Complete and Embase databases were searched by computer. The randomized controlled trial (RCT) of Duhuo Jisheng Decoction combined with west medicine in the treatment of lumbar intervertebral disc hiation was studied. The searching time was from the establishment of the database to July 20, 2019. Data were extracted and analyzed by Revman 5.3 software. Results: Twenty-four literatures involving 1980 patients were included. Meta-analysis showed that the total effective rate of Duhuo Jisheng Decoction group was significantly higher (OR = 5.26, 95％ CI (4.13, 6.69), Z = 13.47, P < 0.00001) and the incidence of adverse reactions was significantly lower (OR = 0.45, 95％ CI (0.23, 0.87), Z = 2.36, P = 0.00001) than that of West medicine group. 02). Conclusion: Duhuo Jisheng Decoction is effective and safe in the treatment of lumbar intervertebral disc hiation. However, the literature included in this study is limited, and the quality of the literature is low. It is necessary to carry out in-depth verification of high-quality, large-sample RCT.