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目的探究大肠肿瘤发病相关危险因素,为大肠癌的针对性防治提供参考依据。方法采用以社区为基础的1∶1配对病例对照研究方法,选取2013年5月—2015年1月上海市金山区朱泾社区卫生服务中心的303例大肠肿瘤患者为病例组,根据年龄和性别配比选取相同数量的对照,采用上海市金山区统一的筛查表收集资料,通过统计分析进行危险因素判定。结果研究结果表明肠息肉史、一级亲属肠癌史、吸烟史可导致大肠肿瘤的发病增加(P<0.05)。肠息肉史OR=13.57,95%CI:1.53~119.98;一级亲属肠癌史OR=1.23,95%CI:1.23~21.45;吸烟史OR=2.01,95%CI:1.18~3.42。结论大肠肿瘤的发生与肠息肉史、一级亲属肠癌史、吸烟史密切相关,对此应重点加强监督防控。
Objective To explore the risk factors associated with the development of colorectal cancer and provide reference for the targeted prevention and treatment of colorectal cancer. METHODS: A community-based 1: 1 matched case-control study was conducted. A total of 303 patients with colorectal cancer from Zhuhai Community Health Service Center, Jinshan District, Shanghai from May 2013 to January 2015 were selected as the case group. According to the age and sex The same number of controls were selected for comparison. Data were collected using a uniform screening table in Jinshan District of Shanghai and risk factors were determined by statistical analysis. Results The results showed that the history of intestinal polyps, first-degree relatives of intestinal cancer history, smoking history can lead to increased incidence of colorectal tumors (P <0.05). Intestinal polyps history OR = 13.57,95% CI: 1.53 ~ 119.98; first-degree relatives bowel cancer history OR = 1.23,95% CI: 1.23 ~ 21.45; smoking history OR = 2.01,95% CI: 1.18 ~ 3.42. Conclusions The occurrence of colorectal tumor is closely related to the history of intestinal polyps, the history of first-degree intestinal cancer and the history of smoking. In this regard, supervision and prevention should be emphasized.