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本文比较了甲硝羟乙唑(M)及其衍生物(CM)对实体瘤的辐射增敏效应。荷S_(180)鼠经腹注药物后在有氧或肿瘤局部急性缺氧下,用γ线照射17GY或不照射,10天内肿瘤生长表明在乏氧下给药后对肿瘤生长有抑制作用,而在有氧下则无影响,CM抑瘤生长比M强;在有氧下照射,各给药组均对瘤生长有明显的抑制,但组间差别不大;在乏氧下照射,给药各组均对瘤生长有明显的抑制作用,其中以CM尤其在CM与Ca~(2+)螯合成CMCa后,对瘤生长抑制最强,抑瘤率达77.4％,ER为2.46,SER为1.89,比单纯照射组及M合并照射组抑瘤作用强,比原化合物M辐射增敏作用大2倍;而毒副作用则较M小,作者对上述结果进行了讨论。
This article compares the radiosensitization effects of metronidazole (M) and its derivatives (CM) on solid tumors. After intragastric administration of the drug, the S_(180) rats were irradiated with γ-irradiation with 17GY or no radiation under aerobic or local acute anoxic conditions. Tumor growth in 10 days showed inhibition of tumor growth after administration under hypoxia. Under aerobic conditions, there was no effect, and CM had a stronger inhibitory effect than M. When irradiated under aerobic conditions, the administration of each group significantly inhibited tumor growth, but there was no significant difference between the groups. Irradiation under hypoxia gave Each group of drugs had a significant inhibitory effect on tumor growth, among which CM, especially CM and Ca 2+ chelated into CMCa, had the strongest inhibitory effect on tumor growth, with a tumor inhibition rate of 77.4% and an ER of 2.46, respectively. At 1.89, the tumor growth was stronger than that of the single irradiation group and the M combined irradiation group, and the radiation sensitization effect was 2 times greater than that of the original compound M. The side effects were smaller than M. The authors discussed the above results.