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慢性创面愈合过程机制复杂,涉及炎性反应、成纤维细胞异常增殖、胶原的形成与沉积、创面血管化和皮肤再上皮化等过程,目前临床缺乏理想的治疗方法.近年来,干细胞的应用在慢性创面的治疗方面备受瞩目,其主要优点是避免了潜在的有害的外科手术过程,避免皮肤移植或皮瓣等手术带来的负荷等.本文就胚胎干细胞、骨髓间充质干细胞、脂肪干细胞、诱导多能干细胞对慢性创面的治疗机制及相关研究进展作一综述.“,”The mechanism of chronic wound healing is complex, which involves inflammatory reaction, abnormal proliferation of fibroblasts, collagen formation and deposition, wound vascularization and skin re epithelialization. At present, there is no ideal treatment method in clinic. In recent years, the application of stem cells has attracted much attention in the treatment of chronic wounds. Its main advantages are avoiding potential harmful surgical procedures and avoiding skin graft or flap operation. In this paper, the treatment mechanism, advantages and disadvantages of embryonic stem cells, bone mesenchymal stem cells, adipose-derived stem cells and induced pluripotent stem cells in chronic wounds were reviewed.