论文部分内容阅读
目的：测定维生素Ｅ微囊在健康家兔体内的药物动力学参数。方法：６只健康家兔随机交叉灌胃服用维生素Ｅ微囊，并用紫外分光光度法测定血浆中的血药浓度。结果：经ＰＫＰＢ－Ｎ１程序包拟合，药－时曲线符合一级吸收的双室模型。动物服用维生素Ｅ微囊后，血浆中药物Ｔ_（１／２Ｋａ）＝３．２４６±１．６６７ｈ，Ｔ_（１／２ａ）＝７．１５０±１．８９９ｈ，Ｔ_（１／２β）＝３８．３０５±３．３４ｈ，达峰时间是１２．１０±３．８０７ｈ，达峰浓度是８．６５２±２．４０４ｍｇ／Ｌ，曲线下面积为２６４．５６±９０．６９．ｍｇ／Ｌ．
Objective: To determine the pharmacokinetic parameters of vitamin E microcapsules in healthy rabbits. Methods: Six healthy rabbits were randomly divided into intragastric administration of vitamin E microcapsules, and the plasma concentration of plasma was determined by UV spectrophotometry. Results: PKPB-N1 package fitting, drug-time curve in line with a two-compartment model of absorption. T_ (1 / 2Ka) = 3.246 ± 1.667h, T_ (1 / 2a) = 7.150 ± 1.899h and T_ (1/2) β = 38 after taking vitamin E microcapsules. 305 ± 3.34h, the peak time was 12.10 ± 3.807h, the peak concentration was 8.652 ± 2.404mg / L, the area under the curve was 264.56 ± 90.69. mg / L.