肿瘤细胞多药耐药是导致肿瘤化疗失败的主要原因之一，也是白血病、肿瘤缓解后复发的重要根源。如何加强对耐药肿瘤细胞的杀灭是目前肿瘤研究领域的重要课题。大黄酸、大黄素与阿霉素、柔红霉素等抗癌药均属于蒽醌类化合物。我们以对阿霉素、柔红霉素已经产生抗药性的三株... The multidrug resistance of tumor cells is one of the main reasons leading to the failure of cancer chemotherapy, and it is also an important source of relapse after leukemia and tumor remission. How to strengthen the killing of resistant tumor cells is an important issue in the field of tumor research. Rhein, emodin, adriamycin, daunorubicin and other anti-cancer drugs belong to steroids. We have three strains that have been resistant to adriamycin and daunorubicin...