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目的分析糖尿病视网膜病变(DR)的危险因素,为DR的防治提供依据。方法 150例2型糖尿病(T2DM)患者按有无DR分为糖尿病非视网膜病变组(NDR组)75例和糖尿病视网膜病变组(DR组)75例,检测其空腹血糖(FBG)、血尿酸(UA)、c-反应蛋白(CRP)、同型半胱氨酸(HCY)、血镁、血钾、血脂、血压等,并进行组间比较,DR与各种影响因素间相关性检验用Logistic多因素逐步回归分析。结果 DR组年龄、病程、收缩压(SBP)、CRP、HCY、UA较NDR组明显升高(P<0.05)、血镁水平较NDR组明显减低(P<0.05)。Logistic分析显示年龄、病程、SBP、CRP、HCY等5个变量是DR发生的独立危险因素。结论除血压和病程等因素外,血CRP、HCY、UA等的升高和血镁的降低可能也与DR的发生有关。
Objective To analyze the risk factors of diabetic retinopathy (DR) and provide evidence for the prevention and treatment of DR. Methods 150 cases of type 2 diabetes mellitus (T2DM) were divided into 75 cases of diabetic retinopathy (NDR group) and 75 cases of diabetic retinopathy group (DR group) with or without DR. The levels of fasting blood glucose (FBG), serum uric acid UA, CRP, HCY, serum magnesium, serum potassium, blood lipid, blood pressure and so on, and compared between groups. The correlation between DR and various influential factors was analyzed by Logistic multi Factors gradually regression analysis. Results The age, course of disease, systolic blood pressure (SBP), CRP, HCY and UA in DR group were significantly higher than those in NDR group (P <0.05). The level of serum magnesium in DR group was significantly lower than that in NDR group (P <0.05). Logistic analysis showed that age, duration of disease, SBP, CRP, HCY and other five variables were independent risk factors for DR. Conclusion In addition to factors such as blood pressure and duration of disease, elevated blood CRP, HCY, UA and other blood magnesium may also be related to the occurrence of DR.