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对海水淹溺肺水肿(PE-SWD)进行高频喷射通气(HFJV)治疗,观察和分析了HFJV对PE-SWD肺弥散功能的影响,探讨HFJV的治疗机制。应用血气酸碱分析仪和计算机图像分析系统,对兔动脉血气酸碱6项指标和肺毛细血管内皮细胞Na+-K+-ATPase9项参数进行自动检测和定量测量。结果表明:HFJV-GPaO_2、血氧饱和应(SO_2)、pH、实际碳酸氢盐(AB)、碱剩余(BE)和肺毛细血管内皮细胞Na+-K+-ATPase活性均比PE-SWD-G明显升高(P<0.01或P<0.05)。但每项指标均未能恢复到淮海水前的正常水平。PaCO_2在两组之间无显著性差异。作者认为,HFJV可较好地增加PE-SWD肺泡弥散面积、减少弥散膜的厚度、调整VA/Q比例失调、改善肺的弥散功能。若与其它救治措施综合应用,可望获得更好的疗效。
HFJV was used to treat pulmonary edema (PE-SWD) in sea water. The effects of HFJV on the diffusion function of PE-SWD lung were observed and analyzed, and the therapeutic mechanism of HFJV was explored. Using blood gas acid-base analyzer and computer image analysis system, 6 parameters of arterial blood gas and acid in rabbits and parameters of Na + -K + -ATPase in pulmonary capillary endothelial cells were detected and quantified automatically. The results showed that HFJV-GPaO2, SO2, pH, AB, BE and Na + -K + -ATPase of pulmonary capillary endothelial cells were significantly higher than that of PE-SWD-G (P <0.01 or P <0.05). However, each indicator failed to recover to the normal level before the Huai Hai water. There was no significant difference in PaCO_2 between the two groups. The authors believe that, HFJV can better increase the PE-SWD alveolar diffusion area, reduce the thickness of the diffusion membrane, adjust the VA / Q ratio imbalance, improve pulmonary diffuse function. If combined with other treatment measures, is expected to get a better effect.