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本文报告10例双向心动过速及应用利多卡因的疗效,3例还有洋地黄所致的房性心动过速(简称房速)伴传导阻滞。男6例、女4例,年龄43～77岁。4例冠心病,3例慢性肺部疾患合并急性肺功能不全,2例二尖瓣脱垂,1例心肌病。8例测定血浆地戈辛浓度,6例升高达3～7μg/ml,其中3例有洋地黄中毒的症状。2例二尖瓣脱垂患者使用洋地黄的情况不详。3例曾记录希氏束电图,证实心动过速来源于心室。利多卡因首剂静脉注射75mg,3分钟后再静注75mg,同时静脉滴注,每分钟3mg,持续7小时。1例首次静注利多卡因75mg后约5分钟发生心室纤颤。2例曾测定血浆利多卡因浓度,在静滴开始时分别为4及4.5mg/L;30分钟后为2.5及3mg/L;60分钟后为2.2及2.5mg/L。9例患者静注利多卡因两次后,
This article reports 10 cases of bidirectional tachycardia and the efficacy of lidocaine, 3 cases also caused by digitalis atrial tachycardia (referred to as atrial tachycardia) with conduction block. 6 males and 4 females, aged 43 to 77 years old. 4 cases of coronary heart disease, 3 cases of chronic lung disease with acute pulmonary insufficiency, 2 cases of mitral valve prolapse and 1 case of cardiomyopathy. 8 cases of determination of plasma Geoxin concentration, 6 cases increased up to 3 ~ 7μg / ml, of which 3 cases of digitalis poisoning symptoms. Two cases of mitral valve prolapse in patients with digitalis is unknown. Three cases had recorded His bundle, confirmed that tachycardia originated in the ventricle. The first dose of lidocaine intravenously 75mg, intravenous infusion of 75mg intravenously after 3 minutes, 3mg per minute for 7 hours. Ventricular fibrillation occurred in about 5 minutes after the first intravenous injection of lidocaine 75 mg. Two of the plasma concentrations of lidocaine had been measured at 4 and 4.5 mg / L at the beginning of the iv infusion; 2.5 and 3 mg / L after 30 minutes and 2.2 and 2.5 mg / L after 60 minutes. After intravenous injection of lidocaine in 9 patients twice,