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某些含蒽酚的轻泻剂(anthranoid laxative)如番泻叶、芦荟、鼠李皮和大黄属等在结直肠癌发病中可能起一定作用,这对长期滥用此类轻泻剂的慢性便秘者更是如此。已证明蒽酚在啮齿动物中有潜在的基因毒性和致癌作用。目前认为,大肠假黑变病(pseudomelanosis coli)是滥用蒽酚类药物超过9～12个月者可靠的且具特异性的参数。 为此,作者等对3049例曾作结直肠镜检查者作回顾性研究,另对1095例患者作前瞻性调查,以了解服用蒽酚类轻泻剂与结直肠疾病,尤其是与结直肠癌发
Certain anthranoid laxatives such as senna, aloe vera, ratapple, and rhubarb may play a role in the pathogenesis of colorectal cancer, which is chronic constipation for chronic abuse of such laxatives. This is even more true. Indophenol has been shown to have potential genotoxicity and carcinogenic effects in rodents. At present, it is considered that pseudomelanosis coli is a reliable and specific parameter for the abuse of indophenolic drugs over 9 to 12 months. For this purpose, the authors conducted a retrospective study of 3049 patients who had undergone colonoscopy, and a prospective survey of 1,095 patients to understand the use of indophenolic laxatives and colorectal diseases, especially with colorectal cancer. hair