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本研究测定1994年南京市热浪袭击期间20例重症中暑患者及12例正常人血浆β-内啡肽浓度变化并对纳洛酮治疗中暑患者的临床效果进行评价。全部中暑病例随机分为纳洛酮治疗组和对照组，每组各10例。各级病例均立即抽取静脉血2ml，纳洛酮治疗组每次静注纳洛酮1．2mg，每次间隔30分钟，共三次，并于每次注药后5分钟各抽取静脉血2ml。纳洛酮治疗组和对照组即刻血浆β-内啡肽含量（各为82．40±16．16ng／L与71．54±11．41ng／L）均较正常人组（31．08±4．86ng／L）显著升高（P＜0．01）；治疗组血浆β-内啡肽含量变化明显地表现为下降趋势，尤以即刻与第二次纳洛酮注射后值（37．00±7．61ng／L）、即刻与第三次用药后值（31．57±7．53ng／L）间差异显著（P＜0．01）；对照组各时间点β-内啡肽值无显著差异（P＞0．05）。第三次注射纳洛酮后，治疗组的收缩压增值及体温、神志、头痛缓解时间与对照组相比，均有显著性差异（P＜0．01）。上述结果提示，纳洛酮可望作为重症中暑抢救的治疗药物之一。
In this study, we measured the plasma concentrations of β-endorphin in 20 severe heat stroke patients and 12 normal subjects during the heat wave attack in Nanjing in 1994 and evaluated the clinical efficacy of naloxone in treating stroke. All cases of heat stroke were randomly divided into naloxone treatment group and control group, 10 cases in each group. 2ml venous blood was drawn immediately from all levels of patients. Naloxone treatment group was intravenously injected with 1.2mg naloxone for 30 minutes each time for 3 times, and 2ml venous blood was drawn for 5 minutes after each injection. The plasma concentrations of β-endorphin (n = 82.40 ± 16.16ng / L and 71.54 ± 11.41ng / L, respectively) in naloxone treatment group and control group were significantly higher than those in normal control group (31.08 ± 4 (P <0.01). The content of plasma β-endorphin in the treatment group obviously showed a downward trend, especially immediately after the second injection of naloxone (37.00 ± 7.61ng / L), and there was a significant difference between the third and the third medication (31.57 ± 7.53ng / L) (P <0.01). The β-endorphin values Significant difference (P> 0.05). The third injection of naloxone, the treatment group systolic blood pressure and body temperature, consciousness, headache relief time compared with the control group were significantly different (P <0.01). The above results suggest that naloxone is expected as one of the treatment of severe heat stroke.