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目的探讨丁苯酞(NBP)对局灶性脑缺血大鼠神经功能恢复的影响,探讨丁苯酞的脑保护作用。方法采用线栓法复制局灶性脑缺血大鼠模型,模型制备成功后,药物组给予NBP灌胃治疗,模型组、假手术组给予等量花生油,分别于术后1d,3d,7d采用Longa 5分制评分标准进行神经功能评定。快速取脑后TTC染色法观察脑梗死体积。结果模型组与假手术组相比Longa评分明显上升(P<0.01),梗死组织明显。NBP治疗组与模型组相比神经行为学明显改善(P<0.01),梗死组织体积明显缩小。结论大鼠脑梗死后神经行为发生变化,梗死组织明显,给予NBP治疗后神经行为明显改善,梗死组织体积缩小,提示NBP可能会促进脑梗死神经功能的恢复,缩短愈后时间,进而提高脑梗死病人的生活质量。
Objective To investigate the effect of butylphthalide (NBP) on the recovery of neural function after focal cerebral ischemia in rats and to explore the protective effect of butylphthalide on brain. Methods The rat model of focal cerebral ischemia was established by thread occlusion. After successful preparation of the model, NBP was given to the rats in the drug group, and the same amount of peanut oil was given to the model group and the sham operation group Longa 5-point scale for neurological evaluation. TTC staining was used to observe the volume of cerebral infarction. Results Compared with sham operation group, Longa score increased significantly (P <0.01) and infarction organization was obvious. NBP treatment group compared with the model group neurological behavior was significantly improved (P <0.01), infarct volume was significantly reduced. Conclusion The neurobehavioral changes and infarction in rats after cerebral infarction are obvious. After NBP treatment, the neurological behaviors are obviously improved and the volume of infarction is reduced. It suggests that NBP may promote the recovery of neurological function after cerebral infarction, shorten the recovery time and further improve the cerebral infarction The quality of life of the patient.