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作者报道一帕金森氏病(PD)妇女在未停服左旋多巴的情况下出现恶性症状群(NMS)的病例。 女性,45岁,1978因右上肢静止性震颤而诊断PD。金刚烷胺、卡别多巴、左旋多巴治疗有效。因出现强直、双上肢震颤、步态障碍而缓慢增加卡别多巴—左旋多巴至60—600mg/日,并加用溴隐亭,有剂末现象出现。1988年7月,出现失眠,抗PD药无效,并多汗,体温38.5℃,而无感染征象,BP142/28mmHg,P100次/分,规则。神经系统检查:神清,
The authors report a case in which women with Parkinson’s disease (PD) developed a series of malignant symptoms (NMS) without stopping levodopa. Female, 45 years old, 1978 PD was diagnosed by resting tremor on the right upper extremity. Amantadine, cardiopodopa, levodopa treatment effective. Due to the emergence of ankylosing spondylitis, upper extremity tremor, gait disorders and slowly increase the card-dopa - levodopa to 60-600mg / day, and add bromocriptine, there agent phenomenon. July 1988, insomnia, anti-PD drugs ineffective, and sweating, body temperature 38.5 ℃, and no signs of infection, BP142 / 28mmHg, P100 beats / min, rules. Neurological examination: God clear,