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目的：探讨白细胞介素－５（ＩＬ－５）在支气管哮喘发病机理中的作用。方法：选择８例哮喘患者雾化吸入人重组ＩＬ－５，并分别于吸入前、吸入后２、２４和４８ｈ采集静脉血分离血清，并以放射免疫法测定血清中嗜酸阳离子蛋白（ＥＣＰ）水平。结果：与吸入ＩＬ－５前基础值［（６．３±１．１）μｇ／Ｌ］相比较，吸入ＩＬ－５后ＥＣＰ水平均随时间而明显升高，至２４ｈ达最高值（１７．６±２．８）μｇ／Ｌ，（Ｐ＜０．０１），４８ｈ后仍维持在较高水平［（１８．１±２．９）μｇ／Ｌ，Ｐ＜０．０１］。结论：吸入ＩＬ－５可以激活循环中嗜酸性粒细胞，从而参与哮喘的发病过程
Objective: To investigate the role of interleukin-5 (IL-5) in the pathogenesis of bronchial asthma. Methods: Eight patients with asthma were selected for inhalation of human recombinant IL-5. Venous blood was collected before inhalation, 2, 24, and 48 hours after inhalation respectively. Serum levels of eosinophilic cationic protein (ECP) were measured by radioimmunoassay. Level. Results: Compared with baseline ([6.3 ± 1.1] μg / L] before inhalation of IL-5, the level of ECP increased significantly with time after IL-5 inhalation, reaching the highest value at 24 hours (17. 6 ± 2.8μg / L, P <0.01), and remained high after 48 hours [(18.1 ± 2.9) μg / L, P <0.01]. CONCLUSION: Inhalation of IL-5 activates circulating eosinophils and is therefore involved in the pathogenesis of asthma