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目的考查虎皮猫用于测定咪唑立宾(MZR)降压物质的效果。方法虎皮猫麻醉后,依次按0.05μg·kg-1、0.10μg·kg-1、0.15μg·kg-1静脉注射磷酸组织胺对照品,测定各剂量磷酸组织胺对猫血压所致的反应值(注射各剂量前后血压的改变幅度),判定猫对磷酸组织胺降压反应的灵敏度。按药典规定方法静脉注射磷酸组织胺和咪唑立宾,观察咪唑立宾在15mg·kg-1、30mg·kg-1、40mg·kg-1剂量下,对猫血压的影响。结果虎皮猫注射不同剂量磷酸组织胺后,血压反应均超过2.67kPa,灵敏度测定合格。每批MZR各剂量dT所致的反应值均不大于ds所致的反应值的一半。结论咪唑立宾降压物质检查符合药典要求,虎皮猫可用于MZR降压物质的检查。
Objective To examine the effectiveness of tiger skin cats for the determination of mizoribine (MZR) antihypertensive substances. Methods After the tiger skin cat was anesthetized, the histamine phosphate reference standard was injected intravenously 0.05μg · kg-1, 0.10μg · kg-1, and 0.15μg · kg-1 in order to determine the response of histamine to the blood pressure of cats Value (before and after the injection of blood pressure changes in the magnitude of), to determine the sensitivity of cats to histamine amine antihypertensive response. According to Pharmacopoeia, intravenous injection of histamine phosphate and mizoribine to observe the effects of midazolam at 15mg · kg-1, 30mg · kg-1 and 40mg · kg-1 on the blood pressure of cats. Results tiger skin cats injection of different doses of histamine phosphate, the blood pressure response were more than 2.67kPa, the sensitivity determination. Each batch of MZR dose dT caused by the reaction value is not greater than the response value of ds half. Conclusion Imidazole Libin antihypertensive substances in line with the requirements of pharmacopoeia, tiger skin cats can be used for MZR antihypertensive substances.