脆骨 -蓝巩膜综合征为遗传性全身结缔组织病 ,较为罕见 ,现将我们遇到的 4例报告如下。例 1,男 ,16岁。因双腕、双膝关节肿痛 2个月于 1996年10月就诊。既往有 3次骨折病史 ,家族史 (- )。体检 :身高160 cm,发育及听力正常。蓝色巩膜 ,双腕、双膝关节轻度肿胀。心、肺、腹 (- ) Brittle - blue scleral syndrome is a hereditary systemic connective tissue disease, is relatively rare, now we encounter 4 cases reported as follows. Example 1, male, 16 years old. Due to double wrist, double knee swelling and pain for 2 months in October 1996 treatment. Past history of fracture 3, family history (-). Physical examination: height 160 cm, normal development and hearing. Blue sclera, double wrists, mild swelling of both knees. Heart, lung, belly (-)