风毛菊(Saussurea DC.)是分布于北温带的菊科二年生草本植物。它在我国分布很广,可全草入药,传统中医药中用于祛风活络,散瘀止痛和麻风,也有用于治疗腹泻。有关风毛菊的细胞分类学和化学成分分析的研究,国内外资料已有报告。但对于致诱变因子诱发的遗传物质损伤的防护作用研究尚未见报道。本文采用小鼠骨髓嗜多染红细胞微核试验(PCE-MNT)、小鼠骨髓细胞染色体畸变试验(CAT)和姐妹染 Saussurea DC. is a biennial herbaceous plant of the Asteraceae family located in the north temperate zone. It is widely distributed in China and can be used as a whole herb. Traditional Chinese medicine is used to activate wind, collaterals, pain, and leprosy. It is also used to treat diarrhea. Research on cell taxonomy and chemical composition analysis of Saussurea purpurea has been reported at home and abroad. However, there has been no report on the protective effect of genetic damage induced by mutagenic factors. In this study, mouse bone marrow polychromatic erythrocyte micronucleus test (PCE-MNT), mouse bone marrow chromosome aberration test (CAT) and sister-dyeing were used.