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Rh(D)抗原的表达有量和质(不完全D抗原)的变化。本文回顾并讨论了已发表的文章和15年来研究D抗原变异的成果。D抗原决定簇决定了单克隆抗D与不完全D抗原的反应模式。不完全D抗原可按D抗原决定簇进行报告,但是有量变化的D抗原(弱D)的细胞抗原决定簇难以通过血液凝集试验进行可靠的鉴定。9种不完全D抗原(Ⅱ～Ⅶ类抗原)DFR抗原和两种以前未报导的抗原,通过其抗原决定簇和与低频抗原的相关性而作出鉴定。单克隆抗-D可鉴别出16种D抗原决定
Rh (D) antigen expression in the quantity and quality (incomplete D antigen) changes. This article reviews and discusses the published articles and the results of a 15-year study of D-antigen variation. The D antigenic determinant determines the mode of response of the monoclonal anti-D to the incomplete D antigen. Incomplete D antigen can be reported as a D antigenic determinant, but a well-defined cellular antigenic determinant of the D antigen (weak D) can not be reliably identified by the blood coagulation assay. Nine incomplete D antigen (class II-Ⅶ antigens) DFR antigens and two previously unrecognized antigens were identified by their antigenic determinants and their association with low-frequency antigens. Monoclonal anti-D identifies 16 D-antigen determinants