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目的了解北京老年医院肺结核病人耐药状况。方法将2002年8月—2008年8月4195例肺结核患者中,对痰培养阳性1125例的结核病人的4种抗结核药物和左氧氟沙星耐药测试的资料进行分析。结果1.耐药病人566例,占50.3%。MDR-TB病人135例,MDR-TB率为12.0%。2.年龄分布以老年为主。3.对任一药累计耐药顺序为S>H>R>E。4.对左氧氟沙星低浓度耐药为32.5%,高浓度为9.0%。结论本院肺结核病例耐药率和耐多药率尚较高,需进一步分析原因,对左氧氟沙星已有一定程度效果,将对MDR-TB的治疗带来影响。
Objective To understand the drug resistance of tuberculosis patients in Beijing Geriatric Hospital. Methods The data of 4 kinds of anti-tuberculosis drugs and levofloxacin resistance test of tuberculosis patients with positive sputum culture of 1195 tuberculosis patients from August 2002 to August 2008 were analyzed. Results 1. 566 resistant patients, accounting for 50.3%. 135 cases of MDR-TB patients, MDR-TB rate was 12.0%. 2. Age distribution mainly in old age. 3. For any drug cumulative resistance sequence S> H> R> E. Low resistance to levofloxacin 32.5%, high concentration of 9.0%. Conclusions The rate of resistance and multidrug resistance in our hospital is still high. Further analysis of the causes suggests that levofloxacin has a certain effect and will affect the treatment of MDR-TB.