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目的:观察分析肺癌患者原发灶脱氧葡萄糖(fluorodeoxyglucose,FDG)摄取与诊断时的淋巴结及远处转移状态的关系。方法:共收集到确诊为肺癌并治疗前行FDG-PET/CT检查患者208例,确定其原发灶大小(CT测量的最大径)、FDG摄取值(最大标准化摄取值,即SU-Vmax)和转移状态,并分为无转移组、仅淋巴结转移组和远处转移组,分析原发灶FDG摄取与原发灶大小和转移情况等的关系,采用Logistic回归分析影响转移的因素。结果:原发灶大小与SUVmax呈正相关性,r=0.613,P=0.000。3组的原发灶大小差异无统计学意义(P=0.078),而SUVmax差异有统计学意义,P=0.008;其中无转移组SUVmax小于仅淋巴结转移组(P=0.041)和远处转移组(P=0.002),后两组间差异无统计学意义,P=0.298。Logistic回归分析表明,SUVmax是唯一影响转移的因素,SUV-max每增加1单位,发生转移的风险增加1.112倍,P=0.032。结论:肺癌原发灶SUVmax增高则发生淋巴结或远处转移的风险增加,提示FDG摄取值可能作为一个预测转移的指标。
OBJECTIVE: To observe the relationship between uptake of fluorodeoxyglucose (FDG) and lymph node metastasis and distant metastasis in patients with primary lung cancer. METHODS: A total of 208 FDG-PET / CT patients were selected and diagnosed as lung cancer. The size of the primary tumor (maximum diameter measured by CT), FDG uptake (maximum normalized value, SU-Vmax) And metastasis, and divided into no metastasis group, only lymph node metastasis group and distant metastasis group, analyze the relationship between primary FDG uptake and primary tumor size and metastasis, using Logistic regression analysis of factors affecting metastasis. Results: There was a positive correlation between primary tumor size and SUVmax (r = 0.613, P = 0.000. There was no significant difference in primary tumor size between the two groups (P = 0.078), but the difference was statistically significant (P = 0.008) There was no significant difference in SUVmax between the two groups (P = 0.041) and distant metastasis group (P = 0.002), P = 0.298. Logistic regression analysis showed that SUVmax was the only factor influencing metastasis. The risk of metastasis increased by 1.112 times for each unit increase of SUV-max, P = 0.032. CONCLUSIONS: Increased SUVmax in primary lung cancer increases the risk of lymph node or distant metastasis, suggesting that FDG uptake may serve as a predictor of metastasis.