胰岛素样生长因子-2(insulin-like growth factor 2,IGF2)基因是最早发现的内源性印迹基因,其表达、调控不遵循孟德尔遗传规律。IFG2是一种多功能细胞增殖调控因子,在细胞的分化、增殖、胚胎的生长发育以及肿瘤细胞增殖中具有重要的促进作用。现就IGF2基因结构与定位、表达机制、生物学意义及其与疾病发生的关系等作一综述。 Insulin-like growth factor-2 (IGF2) gene is the earliest discovered endogenous imprinted gene whose expression and regulation do not follow Mendelian inheritance. IFG2 is a multifunctional cell proliferation regulator that plays an important role in cell differentiation, proliferation, embryonic growth and tumor cell proliferation. Now on the IGF2 gene structure and location, the expression mechanism, the biological significance and the relationship between the disease and so on are reviewed.