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目的评估超声引导下微波消融联合乙醇注射治疗兔肝VX2瘤的可行性和安全性。方法 30只新西兰大白兔于肝脏上移植VX2瘤,2周后经超声造影确认肿瘤移植成功后,MW组(15只)和MP组(15只)分别接受超声引导下微波消融治疗和微波消融联合无水乙醇注射治疗。治疗结束后1周,将动物处死,取出肝脏观察消融范围。结果种植VX2瘤后2周,MW组和MP组分别有13只和14只兔子成瘤。两组兔子均耐受治疗,MP组消融范围明显大于MW组(P<0.01)。消融后大体标本显示,MP组形态欠规则。HE染色显示,两组病理组织无明显差异。结论微波消融联合乙醇注射治疗兔肝VX2瘤安全、有效。
Objective To evaluate the feasibility and safety of ultrasound-guided microwave ablation combined with ethanol injection in the treatment of VX2 tumors in rabbits. Methods Thirty New Zealand white rabbits were transplanted with VX2 tumors on the liver. Two weeks after the transplanted tumor was confirmed by ultrasound contrast, the MW group (15) and the MP group (15) underwent ultrasound-guided microwave ablation and microwave ablation Absolute ethanol injection treatment. One week after the treatment, the animals were sacrificed and the liver removed to observe the extent of ablation. Results Two weeks after VX2 tumor implantation, 13 and 14 rabbits in MW and MP groups, respectively, developed tumors. Rabbits in both groups were tolerant to treatment, and the extent of ablation in MP group was significantly greater than that in MW group (P <0.01). The gross specimen after ablation showed that the morphology of MP group was underdeveloped. HE staining showed no significant difference between the two groups of pathological tissue. Conclusion Microwave ablation combined with ethanol injection in the treatment of VX2 rabbit liver is safe and effective.