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目的观察阿司匹林联合阿托伐他汀钙治疗脑血栓的临床疗效。方法选取该院神经内科2014年10月-2015年10月收治的脑血栓患者80例,采用随机分组法将其分为观察组与对照组各40例,观察组采用阿司匹林联合阿托伐他汀钙治疗,对照组采用阿司匹林治疗。比较2组患者的治疗效果、神经功能缺损评分(NIHSS)、Barthel指数评分、颈内动脉内膜—中层厚度(IMT)及不良反应发生率。结果观察组总有效率为92.5%明显高于对照组的77.5%,差异有统计学意义(P<0.05);治疗后2组NIHSS评分和IMT较治疗前均降低,Barthel指数评分较治疗前升高,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为2.5%低于对照组的12.5%,差异有统计学意义(P<0.05)。结论阿司匹林联合阿托伐他汀钙治疗脑血栓效果显著,能明显改善患者的病情,减少不良反应的发生,提高患者生活质量,值得在临床上推广运用。
Objective To observe the clinical efficacy of aspirin combined with atorvastatin calcium in the treatment of cerebral thrombosis. Methods Eighty patients with cerebral thrombosis who were treated in Department of Neurology from October 2014 to October 2015 in our hospital were divided into observation group (40 cases) and control group (40 cases) randomly. The observation group was treated with aspirin combined with atorvastatin calcium The patients in the control group were treated with aspirin. The treatment effect, neurological deficit score (NIHSS), Barthel index score, carotid intima-media thickness (IMT) and incidence of adverse reactions in two groups were compared. Results The total effective rate in the observation group was 92.5%, which was significantly higher than that in the control group (77.5%, P <0.05). After treatment, the NIHSS scores and IMT in both groups were lower than those before treatment, and the Barthel index score was higher than that before treatment (P <0.05). The incidence of adverse reactions in the observation group was 2.5% lower than that in the control group (12.5%), the difference was statistically significant (P <0.05) . Conclusion Aspirin combined with atorvastatin calcium treatment of cerebral thrombosis significant effect, can significantly improve the patient’s condition, reduce the incidence of adverse reactions, improve patient quality of life, it is worth to promote the use of the clinic.