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目的回顾分析药源性耳毒性的药品及其作用机制。方法检索1998年1月～2010年12月国内医药期刊报道的病例进行统计分析。结果 166例病例纳入分析,引发耳毒性的非氨基糖苷类药物种类各异,主要包括抗感染药,利尿药,水杨酸类制剂、麻醉药、抗肿瘤药,儿童,老年人,肝肾功能不全者易引发耳毒性,1～30天为高发期。结论非氨基糖苷类药物引发耳毒性可造成耳鸣、耳聋、眩晕和平衡失调,临床医务人员应引起重视。
Objective To review the drug-induced ototoxicity and its mechanism of action. Methods The data of cases reported in domestic medical journals from January 1998 to December 2010 were collected for statistical analysis. Results A total of 166 cases were included in the analysis. The types of non-aminoglycoside drugs that cause ototoxicity include anti-infectives, diuretics, salicylates, anesthetics, antineoplastic agents, children, the elderly, liver and kidney function Incomplete can lead to ototoxicity, 1 to 30 days for the high incidence. Conclusion Non aminoglycoside - induced ototoxicity can cause tinnitus, deafness, dizziness and imbalance, and clinicians should pay attention to it.