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目的通过检测血清唾液酸(SA)在原发性肝癌(PHC)中的活性水平并与甲胎蛋白(AFP)进行比较,评价SA对PHC的诊断价值。方法收集原发性肝癌43例、肝硬化22例、慢性肝炎20例和急性肝炎21例及正常对照组20例,同时采用酶速率法测定SA的活性水平;采用免疫放射分析固相双位点夹心法测定AFP,检测结果进行比较分析。结果PHC患者血清SA、AFP浓度显著高于正常对照组和其它肝病组(P<0.05);在PHC患者中,SA、AFP单项检测的阳性率分别为53.5%和72.1%,两项联合检测阳性率则可提高至86%,高于SA或AFP的单项检测。结论血清SA检测对PHC患者的确诊具有重要的辅助价值。
Objective To evaluate the diagnostic value of SA for PHC by detecting the level of serum sialic acid (SA) activity in primary hepatocellular carcinoma (PHC) and comparing it with that of AFP. Methods 43 cases of primary liver cancer, 22 cases of liver cirrhosis, 20 cases of chronic hepatitis and 21 cases of acute hepatitis and 20 cases of normal control were collected. Meanwhile, the activity of SA was measured by enzyme-linked immunosorbent assay (ELISA) Sandwich assay AFP, test results were compared. Results The serum levels of SA and AFP in PHC patients were significantly higher than those in normal controls and other liver disease groups (P <0.05). In PHC patients, the positive rates of SA and AFP were 53.5% and 72.1% Rate can be increased to 86%, higher than the single test SA or AFP. Conclusions Serum SA test has important auxiliary value for the diagnosis of PHC patients.