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目的：探讨丙泊酚复合布托啡诺用于无痛人流手术的麻醉效果和安全性。方法门诊无痛人流手术孕妇50例，随机分为丙泊酚组(P组)和布托啡诺组(B组)，每组25例。P组静注丙泊酚3mg?kg-1，B组静注布托啡诺1mg+丙泊酚2.5mg·kg-1，待孕妇意识消失后开始手术，术中若体动影响手术则追加丙泊酚30mg。记录麻醉前(T0)、麻醉后2min(T1)，4min(T2)和手术结束时(T3)的MAP、HR和SpO2；记录手术时间、苏醒时间、出院时间、丙泊酚用量、麻醉效果评级、不良反应(术中呼吸抑制、术后头晕、恶心呕吐)的发生情况和术后下腹痛VAS评分。结果丙泊酚用量B组低于P组(P<0.05)；组内MAP和HR比较，两组T1、T2高于T0(P<0.05)；组间MAP和HR比较，B组在T1、T2低于P组(P0.05)；麻醉效果和下腹痛VAS评分B组优于P组(P0.05)。结论丙泊酚复合布托啡诺用于无痛人流手术可获得满意的麻醉效果，减少丙泊酚用量，减轻术后下腹疼痛，不良反应发生率低。“,”Objective:To evaluate the anesthetic effect and safety of propofol combined with butorphanol on painless abortion surgery.Methods:50 pregnant women scheduled to undergo painless abortion surgery in outpatient department were randomly divided into two groups (n=25 each): the propofol group (group P) and the butorphanol group (group B).The pregnant women in group P received propofol 3 mg kg-1 i.v.,while received butorphanol 1 mg and propofol 2.5 mg.kg-1 in group B. The operation was begun after pregnant women fal asleep. Propofol 30 mg was administered i.v.if the operation was disturbed by the movement of pregnant women.MAP, HR and SpO2 were recorded before injection, at 2,4 min after injection and the end of operation. The time of operation, opening eyes, and leaving hospital were recorded. The dosage of propofol, anesthesia effect rating, incidence of adverse reactions(including hypoxia, dizzy, nausea and vomiting)and VAS were recorded.Results:Dosage of propofol and VAS were reduced in group B compared with group P (P<0.05). Anesthesia effect rating was better in group B compared with group P (P<0.05). MAP and HR at 2,4 min after injection were reduced in group B compared with group P (P<0.05), while were increased after injection in two groups(P<0.05). No differences were found with SpO2 and adverse reactions among two groups (P<0.05).Conclusion:Propofol combined with butorphanol used in painless abortion surgery can achieve good anesthetic effect, while reducing dosage of propofol, postoperative pain and incidence of adverse reactions.