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目的 :观察银杏外种皮多糖制剂对胃癌的临床疗效及超微结构的影响。方法 :2 8例胃癌患者给予银杏外种皮多糖胶囊 ,po,每次 2粒 ,bid ,30d为 1个疗程 ,连服 1～ 3个疗程。治疗前后用电子胃镜观察并测量瘤体大小 ,用透射电子显微镜观察瘤细胞的超微结构 ,用图像分析仪对瘤细胞进行图像分析 ,计算核质比及异染色质面密度 ,同时观察患者的主要临床表现。结果 :银杏外种皮多糖可使胃癌患者的疼痛减轻、食欲增强 ,可使胃癌瘤体缩小 ,抑制率为 4 8% ,有效率为 78.5 %。超微结构观察提示银杏外种皮多糖有诱导癌细胞凋亡和分化迹象。结论 :银杏外种皮多糖制剂对胃癌有治疗作用。诱导癌细胞凋亡和分化可能是其抗肿瘤作用机制之一。
Objective: To observe the clinical effect and ultrastructure of ginkgo exocarp polysaccharide on gastric cancer. Methods: Twenty-eight gastric cancer patients were given ginkgo exocarp polysaccharide capsules, po, two capsules each time, bid, 30d for a course of treatment, and even for 1 to 3 courses. Before and after treatment, the size of the tumor was observed by electron gastroscope, the ultrastructure of tumor cells was observed by transmission electron microscope, the tumor cells were imaged by image analyzer, and the density of nucleoplasm and heterochromatin were calculated. At the same time, The main clinical manifestations. Results: Ginkgo biloba exocarp polysaccharide can reduce the pain of patients with gastric cancer, increased appetite, gastric cancer can be reduced, the inhibition rate was 48%, the effective rate was 78.5%. Ultrastructural observation indicated that Ginkgo biloba exocarp polysaccharides induced apoptosis and differentiation of cancer cells. Conclusion: Ginkgo exocarp polysaccharide preparation has a therapeutic effect on gastric cancer. Induction of apoptosis and differentiation of cancer cells may be one of its anti-tumor mechanisms.