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对中南地区10个钨矿1972—1974年入矿(工龄至少1年)的在册职工28453人进行了队列研究。队列成员追访至1989年,死亡2870人,比全国居民死亡率计算的期望值略高(SMR=1.15,95％CI=1.11—1.19);主要是非恶性呼吸道疾病,特别是尘肺(SMR=66.79,95％CI=59.65—73.68)以及与呼吸道疾病相关的肺心病明显超高(SMR=8.19,95％CI=7.42—9.02),比全国居民死亡率高5倍。癌症死亡数在全死因中虽占第一位,但仅鼻咽癌轻度超高(SMR=1.73,95％CI=1.23—2.37),而肺癌死亡率明显偏低(SMR=0.53)。研究结果不支持矽肺与肺癌病因学相关的假说。
A total of 28 453 registered workers were enrolled in 10 tungsten mines in Central South China from 1972 to 1974 (at least one year of service). The cohorts of members of the cohorts traced to 1989 with 2870 deaths, slightly higher than the expected national mortality rate (SMR = 1.15, 95% CI = 1.11-1.19); mainly non-malignant respiratory diseases, especially pneumoconiosis (SMR = 66.79, 95% CI = 59.65-73.68) and pulmonary heart disease associated with respiratory disease were significantly higher (SMR = 8.19, 95% CI = 7.42-9.02), 5 times higher than the national mortality rate. Although the number of cancer deaths ranked first in all causes of death, only nasopharyngeal cancer was mildly hyperactive (SMR = 1.73, 95% CI = 1.23-2.37), whereas lung cancer mortality was significantly lower (SMR = 0.53). The findings do not support the hypothesis that etiology of silicosis and lung cancer are related.