随着淋巴管特异性因子血管内皮生长因子-C的发现,学者们相继发现了多种促进肿瘤局部淋巴结转移的因子。近年来,虽然热疗与肿瘤转移关系的研究主要还是停留在临床方面,但是随着基础研究的深入,学者们发现,热疗能抑制促进肿瘤局部淋巴结转移因子的生成。本文就促进肿瘤局部淋巴结转移的相关因子及其与热疗关系的研究进展作一综述。 With the discovery of the lymphatic vessel-specific factor Vascular Endothelial Growth Factor-C, many researchers have found a variety of factors that promote the local lymph node metastasis. In recent years, although the study of the relationship between hyperthermia and tumor metastasis remains mainly in clinical aspects, with the further research, scholars found that hyperthermia can inhibit the generation of local lymph node metastasis factor. This review summarizes the related factors that promote the local lymph node metastasis and its relationship with hyperthermia.