以颞浅动静脉为受区血管的游离股前外侧皮瓣在上颌骨恶性肿瘤术后缺损修复中的临床应用

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目的:探讨以颞浅动静脉作为受区血管的游离股前外侧皮瓣对上颌骨恶性肿瘤切除术后缺损修复的功能与美容效果。方法:回顾性分析2014年1月至2019年11月,中南大学湘雅二医院口腔颌面外科采用颞浅动静脉作为受区血管行上颌骨全切术的21例上颌骨恶性肿瘤患者的病例资料,男18例,女3例,年龄29~73岁。其中鳞状细胞癌19例,腺样囊性癌1例,骨肉瘤1例。7例患者为一期手术;14例患者为再次手术,其中13例为同侧第2部位肿瘤再发,1例为肿瘤复发,既往有术后放化疗史者6例。上颌骨组织大面积缺损用股前外侧皮瓣修复。术后1、3、6个月定期门诊复查,采用洼田饮水试验、语音清晰度评判患者口腔功能重建效果。采用SPSS 22.0软件对数据进行统计分析,手术前后洼田饮水试验的结果比较采用Wilcoxon秩和检验,手术前后语音清晰度比较采用配对n t检验。n 结果:随访10个月~5年,21例患者皮瓣完全成活,伤口愈合良好,无严重并发症发生。外形恢复满意,均无复视,鼻腔通气良好,进食正常,下肢负重、行走不受影响。洼田饮水试验均未发现流水流入鼻腔的现象,无口鼻漏。其中洼田饮水试验结果评级Ⅰ级4例,Ⅱ级13例,Ⅲ级3例,Ⅳ级1例。21例患者术前汉语语音清晰度评分为(4.31±0.13)分,术后1个月复查评分为(1.46±0.21)分,3个月时评分为(2.15±0.45)分,6个月时为(2.87±0.76)分,术后6个月复查较术后1个月语音清晰度明显改善,差异有统计学意义(n F=78.456,n P<0.05)。n 结论:使用颞浅动静脉作为受区血管的股前外侧皮瓣进行修复重建手术易于操作,安全可靠,患者术后外形和功能恢复良好。“,”Objective:To study the effects of superficial temporal artery and vein as recipient vessels for the free anterolateral thigh flap on the appearance and functions after maxillectomy.Methods:Clinical data of 21 patients with malignant maxillary tumors in Department of Oral and Maxillofacial Surgery, the Second Xiangya Hospital of Central South University from January 2014 to November 2019, who were treated by free anterolateral thigh flap with temporal superficial vessels as the recipient vessels were analyzed retrospectively. There were 18 males and 3 females, with the age ranging from 29 to 73 years old, including 19 cases of squamous carcinoma, 1 case of adenoid cystic carcinoma and 1 case of osteosarcoma. Of those 7 patients underwent primary surgery, 14 patients received resurgery, and 6 patients had a history of postoperative radiotherapy and chemotherapy. Among 14 patients with resurgery, 13 had recurrent ipsilateral second site tumor and 1 had recurrent tumor, and all of them received the maxillectomy and reconstructive surgery with the free anterolateral thigh flap. Patients were evaluated with water swallow test and speech intelligibility score in 1, 3 and 6 months after operation. The data were statistically analyzed with SPSS 22.0 statistical software. Water swallow test results before and after operation were compared using the Wilcoxon rank sum test. The mean speech intelligibility scores before and after operation were compared by the paired n t test.n Results:Patients were followed up for 10-60 months. All free flaps survived after operation. No diplopia occurred. Breathing, swallowing and speaking functions were normal. No movement disorders caused by the donor of thigh flap. Water swallow test showed no phenomenon of water flowing into the nasal cavity or oral and nasal leakage with level Ⅰ for 4 cases, level Ⅱ for 13 cases, level Ⅲ for 3 cases and level Ⅳ for 1 case. The mean speech intelligibility scores before surgery and 1, 3 and 6 months after surgery were 4.31±0.13, 1.46±0.21, 2.15±0.45 and 2.87±0.76 respectively. There was statistically significant difference in the mean speech intelligibility scores between 1 and 6 months after surgery (n F=78.456, n P<0.05).n Conclusion:It is safe and reliable to use the superficial temporal vessels as recipient vessels for free anterolateral thigh flap in the reconstruction of defect after maxillectomy in malignant tumors, with good outcomes of functions and a satisfactory restoration of outward appearance.
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深度学习已广泛应用于缺血性脑卒中的影像学研究中,包括梗死核心与缺血半暗带的测量、最终梗死容积与侧支循环的分析、卒中发病时间与亚型的判断等方面,以期实现对卒中的个体化精准诊断,但也遇到了诸多问题。笔者就此领域的临床应用与挑战进行综述。