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为观察肠血管活性多肽 (VIP )及生长抑素 (SST )对大鼠肠淋巴细胞在肠相关淋巴组织归巢的影响 ,本实验将 18只大鼠随机分为三组 ,每组 6只 ,分别从股静脉输入生理盐水、VIP组或SST ,从肠系膜淋巴管插管引流淋巴液。结果显示 ,大鼠经静滴VIP或SST后 ,5h内肠系膜淋巴管淋巴细胞总数降低 (P <0 0 5 ) ;肠淋巴液量和对照组比较无显著改变 (P >0 0 5 ) ;每毫升淋巴液中细胞数降低 (P <0 0 5 )。VIP组和SST组肠淋巴液中CD8+ 细胞比例降低 (P <0 0 5 )。两实验组回肠粘膜CD8+ 细胞数降低 (P <0 0 5 )。VIP或SST能减少肠粘膜CD8+ 淋巴细胞与其他器官及系统免疫的沟通 ,也抑制从其他器官及系统免疫中归巢至肠粘膜的CD8+ 细胞
In order to observe the effect of VIP and SST on gut-associated lymphoid tissue homing in rat intestine, 18 rats were randomly divided into three groups (6 in each group) From the femoral vein, saline, VIP group or SST were respectively administered to drain the lymph from the mesenteric lymphatic duct. The results showed that the total number of lymphocytes in mesentery lymphatic vessels within 5h after intravenous infusion of VIP or SST decreased (P <0 05), and there was no significant change in intestinal lymph volume compared with the control group (P> 0.05) The number of cells in the ml lymph decreased (P <0 05). The percentage of CD8 + cells in intestinal lymph of VIP group and SST group decreased (P <0.05). The number of CD8 + cells in the two experimental groups decreased (P <0.05). VIP or SST can reduce the intestinal mucosal CD8 + lymphocytes and other organs and systemic immune communication, but also from other organs and immune system to suppress the homing to the intestinal mucosa of CD8 + cells