机体在急性感染时通常都会出现厌食行为,此种饮食行为的改变对于不同类型感染引起的炎症是至关重要的。来自美国耶鲁大学医学院免疫生物研究所的Medzhitov教授及其团队以小鼠为模型,围绕着这种常见的厌食行为展开研究,探讨了细菌与病毒性炎症中厌食后的新陈代谢对组织耐受力的不同影响及其分子机制。研究者首先利用李斯特菌感染与LPS诱导的全身感染的小鼠模型,结合葡萄糖的供给或者葡萄糖的利用抑制展开研究, Anorexia is usually present in the body during acute infections and this change in dietary behavior is crucial for the inflammation caused by different types of infections. Professor Medzhitov from the Institute of Immunology, Yale University School of Medicine and his team from the United States used mouse models to investigate this common anorexia behavior and explored the metabolic tolerance of bacteria and viral inflammation to anorectal tissue The Different Influences and Their Molecular Mechanisms. The researchers first used the Listeria infection and LPS-induced systemic infection in mice model, combined with the supply of glucose or glucose utilization inhibition study,