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泛素(Ubiquitin)系统是目前已知最重要且有高度选择性的蛋白质降解体系。近来许多研究发现该系统在免疫信号转导过程中发挥重要的调控功能。泛素系统可以通过识别某些酪氨酸磷酸化标记的免疫细胞膜受体使其降解,从而终止免疫信号转导。另外,在免疫系统重要转录因子NF-κB活化的不同阶段也有泛素系统参与。通过作用于免疫信号转导过程的上述环节,泛素系统调控免疫应答及炎症反应,本文拟就有关内容作一综述。
The ubiquitin system is the most important and highly selective protein degradation system known to date. Recently, many studies have found that this system plays an important regulatory role in the process of immune signal transduction. Ubiquitin systems can terminate immune signaling by recognizing certain tyrosine phosphorylation-tagged immune cell membrane receptors that degrade them. In addition, ubiquitin system is also involved in the different stages of activation of NF-κB, an important transcription factor of the immune system. The ubiquitin system regulates the immune response and inflammatory response by acting on the above steps in the process of immune signal transduction. This article intends to review the relevant contents.